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Pharmaceutical

Pfizer Halts Studies on Osteoarthritis Drug

June 23, 2010
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The Associated Press reports Pfizer Inc. has suspended clinical trials of its drug tanezumab as a potential osteoarthritis treatment, after some patients'' conditions worsened. Pfizer said it halted the worldwide program following a request by the Food and Drug Administration after reports of a "small number" of patients experiencing more severe osteoarthritis that led to joint replacement. Osteoarthritis is a chronic breakdown and eventual loss of cartilage in the joints. The clinical hold includes both suspending recruitment of new patients and the dosing of existing patients in the osteoarthritis program, as well as patients with osteoarthritis in other studies. Pfizer said the adverse event has not been observed in patients without osteoarthritis that are taking tanezumab. The drug also is being developed as a potential treatment for lower back pain and bone cancer pain.
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