Spiroflow Systems specializes in "high containment" powder handling solutions and offer a range of bulk bag unloaders specifically for use in pharmaceutical applications. Improperly handled bulk bags can cause dust and spillage during discharge and afterwards during the disposal of empty bags. Its pharmaceutical bulk bag unloaders offer total containment of bulk bags during discharge and their subsequent removal. They come complete with a liner spout clamping system that ensures the total containment. Patented interlocked power operated pinch bars clamp the bulk bag neck so that the neck ties can be released safely. Depending on the potency of the active ingredient, releasing the neck ties, cutting open sealed liners, feeding them through the clamp ring and over the discharge spout all takes place within a negative pressure enclosure connected to a HEPA filtration system either through an access door or through a sealed glove box arrangement. The liner clamp has the option of pneumatic or manual operation.