Processing Magazine

Better wet granulation: development, scale-up and manufacture

April 3, 2012

Wet granulation is a common unit operation, particularly in the pharmaceutical industry, yet accurate endpoint detection remains a challenge. In this free download, Tim Freeman, Managing Director of Freeman Technology, examines the contribution that dynamic powder rheometry can make, highlighting its ability to detect the transition from wet mass to granulate with the required sensitivity. Quantification of this transition point, with a measure that is independent of process scale, accelerates development and scale-up and improves manufacture.