The in-line mixer systems are high-speed, easy-to-clean, and rapidly disperse materials in liquids to enhance a product’s stability, viscosity, texture, color, or flavor. The high-speed mixer passes the entire slurry through a high-shear mixing head for continuous in-line processing or recirculation through a tank. Producing a highly uniform and repeatable product, these systems include a pump, valves, stainless steel tank, piping with quick-disconnects, and cleanup easily with minimal waste. The unit can be configured to precise user process requirements through its custom engineered design. It can also be designed for handling viscous materials from 1,000 CPS and up with flow rates from 0.5 to 300 GPM; requiring dispersion down to one micron, with ±1% repeatability, depending upon the ingredients and application.