PAT-Ready production scale for the pharmaceutical industry
October 18, 2005
Process Analytical Technology (PAT)-Ready options are available for the company’s production level M-700 series Microfluidizer® high-shear fluid processors. PAT is an FDA framework for designing, analyzing, and controlling the pharmaceutical manufacturing cycle. Unlike the batch processing common on today’s drug manufacturing, PAT will allow continuous process streams to be digitally measured, monitored, and controlled. The PAT-ready options for the M-700 series include SCADA and DCS industry standard technology for data acquisition and process control. With these options, pharmaceutical manufacturers can incorporate Microfluidizer processors into their product manufacturing lines while monitoring variables of flow, pressure, and temperature within a closed loop control environment. PAT-Ready options are also available with the constant pressure option that utilizes intelligent built-in pump position transducers that automatically adapt to changing requirements and easily maintain constant process pressure. This full digital control of the dual synchronous high-pressure intensifier pumps ensures that the product flows at constant pressure and velocities through the interaction chambers. This control eliminates pressure spikes, provides extremely uniform processing, and permits the M-700 system to operate more quietly and efficiently.