The Associated Press reports that a pharmaceutical products subsidiary of Sigma-Aldrich Corp. is planning a $4.5 million expansion of its chemical manufacturing facility in Madison, Wisconsin. The plan, scheduled for commission in early 2008, will add more pilot plant and lab capacity and complement new analytical equipment for advanced solid form testing due to become operational this month. SAFC, the fine chemicals segment of St. Louis-based Sigma-Aldrich, plans to add two pilot plant reactors and two portable jacketed reactors into a 1,200-square-foot lab. The addition will enable larger-scale chromatography for process purification. The Madison facility is part of SAFC Pharma, which provides manufacturing, process development and contract services for pharmaceutical ingredients and advanced intermediates, and the development of large molecule biopharmaceuticals. The developments build upon existing capabilities in potent compound handling at the SAFC Madison facility and add to a $12 million, 38,000-square-foot expansion completed in 2006.